| 两种新型1-烷基咪唑类双膦酸的合成与表征 |
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| 引用本文： | 南蓓蓓,邱玲,林建国,马海霞. 两种新型1-烷基咪唑类双膦酸的合成与表征[J]. 化学试剂, 2011, 0(11): 971-974 |
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| 作者姓名： | 南蓓蓓 邱玲 林建国 马海霞 |
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| 作者单位： | 西北大学化工学院;江苏省原子医学研究所卫生部核医学重点实验室江苏省分子核医学重点实验室; |
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| 基金项目： | 国家自然科学基金资助项目(20801024); 江苏省自然科学基金资助项目(BK2009077); 吴阶平医学基金资助项目(320.6750.08056) |
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| 摘 要： | 分别以1-乙基咪唑和1-丁基咪唑为原料,经过羟甲基化、溴代、氰解、酸性水解、膦酰化5步反应,合成了两种新型的唑来膦酸衍生物,通过元素分析、IR、MS和1HNMR测定对目的产物进行了结构确认.
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| 关 键 词： | 唑来膦酸衍生物 双膦酸 合成 |
Synthesis and characterization of two novel 1-alkyl imidazole diphosphonic acid |
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| NAN Bei-bei,,QIU Ling,LIN Jian-guo,MA Hai-xia. Synthesis and characterization of two novel 1-alkyl imidazole diphosphonic acid[J]. Chemical Reagents, 2011, 0(11): 971-974 |
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| Authors: | NAN Bei-bei QIU Ling LIN Jian-guo MA Hai-xia |
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| Affiliation: | NAN Bei-bei1,2,QIU Ling2,LIN Jian-guo2,MA Hai-xia*1 |
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| Abstract: | Two novel zoledronic acid derivatives were prepared by hydroxymethylation,bromination,cyano substitution,acid hydrolysis and phosphine acylation from the raw material of 1-ethyl-1H-imidazole and 1-butyl-1H-imidazole respectively.The products were characterized by elemental analysis,IR,MS and 1HNMR techniques. |
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| Keywords: | zoledronic acid derivatives bisphosphonic acid synthesis |
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