N-甲基-2,2-二(4-苯氧基苯氧基)乙酰胺的合成

二氯乙酸甲酯与甲胺反应,制备了中间体N-甲基二氯乙酰胺。在无水碳酸钾存在下,以N,N-二甲基甲酰胺(DMF)为溶剂,中间体与4-苯氧基苯酚反应得到目的产物。着重考察了反应温度、反应时间、物料投料比对目的产物收率的影响,从而确定了产物的合成工艺条件为:反应温度85°C,反应时间4h,物料投料比n(N-甲基二氯乙酰胺)∶n(4-苯氧基苯酚)=1.0∶2.2。在此条件下,产物的收率达82%以上。经IR、MS、1H NMR确定为N-甲基-2,2-二(4-苯氧基苯氧基)乙酰胺。

Synthesis of N-Methly-2,2-bis(4-phenoxyphenoxy) acetamide

N-methyl dichloroacetamide was synthesized by the reacteon of methylamine and methyl dichloroacetate.N-methyl-2,2-bis(4-phenoxyphenoxy)acetamide was prepared from 4-phenoxyphenol and N-methly dichlorocetamide using N,N-dimethyl formamide(DMF) as solvent in the presence of anhydrous potassium carbonate.The effect of feed composition,rection temperature and reaction time on the yield of N-methyl-2,2-bis(4-phenoxyphenoxy)acetamide was investigated.The optimal conditions obtained were:reaction temperature,85°C;reaction time,4 h;and n(N-methyl dichloroacetamide)∶n(4-phenoxyphenol)=1.0∶1.2.The yield of N-methyl-2,2-bis(4-phenoxyphenoxy)acetamide reached 82%.The structure of N-methyl-2,2-bis(4-phenoxyphenoxy)acetamide was characterized by IR、MS、1H NMR.