Inhibition of DNA topoisomerase I activity by diethylstilbestrol and its analogues |
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| Authors: | T Oda Y Sato M Kodama M Kaneko |
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| Affiliation: | Kyoritsu College of Pharmacy, Tokyo, Japan. |
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| Abstract: | ![]()
Diethylstilbestrol and its derivatives were tested to determine their inhibitory effects on the relaxation activity of DNA topoisomerase I using cell lysates from Chinese hamster V79 cells. Among the derivatives investigated, (+/-)-indenestrol B, (+/-)-IB, showed the strongest inhibitory effect. |
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