Metronidazole–Deoxybenzoin Derivatives as Anti‐Helicobacter pylori Agents with Potent Inhibitory Activity against HPE‐Induced Interleukin‐8 |
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| Authors: | Yin Luo Dr. Huan‐Qiu Li Dr. Yang Zhou Dr. Zi‐Lin Li Tao Yan Dr. Hai‐Liang Zhu Prof. |
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| Affiliation: | State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093 (PR China), Fax: (+86)?25‐8359 2572 |
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| Abstract: | ![]()
A series of new metronidazole–deoxybenzoin derivatives were synthesized and evaluated for their antimicrobial activity against Helicobacter pylori. Highly selective anti‐H. pylori activity was also observed in synthesized compounds. Compound 34 exhibited the most potent activity, similar to the positive control amoxicillin. Furthermore, compounds 17 and 34 were able to significantly decrease H. pylori water extract (HPE)‐induced production of interleukin‐8 (IL‐8) in gastric mucosal cells, which did not show any effect on the cell viability. |
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| Keywords: | deoxybenzoins Helicobacter pylori HPE‐induced IL‐8 metronidazole |
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