聚ε-己内酯/聚乙二醇共混纳米纤维的静电纺丝研究

采用四氢呋喃和无水乙醇为溶剂,利用静电纺丝法制备了聚己内酯(PCL)/聚乙二醇(PEG)共混纳米纤维。研究了共混配比、溶液浓度、无水乙醇的加入以及电纺电压、接收距离等工艺参数对纤维形态和性能的影响。测试结果表明:聚乙二醇和聚己内酯以一定比例共混后改善了聚己内酯纤维毡的亲水性和细胞相容性;随着纺丝原液浓度增加,电纺产品由高分子微/纳米液滴结构渐变为珠状结构较少的平滑纤维,平均纤维直径逐渐增大;一定范围内,纤维平均直径随电压的上升而增大,但与接收距离关系不大;此外,加入无水乙醇后,共混溶液电导率增加,有利于喷射流的劈裂,减少了珠状结构的数量。

Study on PCL/PEG Blending Nanofibers by Elecrtospinning

Polycaprolactone(PCL) blended with poly(ethylene glycol)(PEG) was dissolved in the mixture of terahydrofuran(THF) and ethanol to prepare PCL/PEG nanofibers by electrospinning.The effects of blending ratio,concentration of spinning solution,solvent mixture,voltage and distance between the capillary and collecting screen were studied.The results showed that the hydrophilicity and biocompatibility of PCL mats could be improved by blending with PEG.With the increase of the solution concentration,the products of the electrospinning were transformed from some micro/nano macromolecule droplets to some smooth fibers having less beads,while the average fiber diameter was increased.Under the certain extent,the average fiber diameter was increased as the voltage increasing but almost irrelevant to the distance between the capillary and collecting screen.Besides,the conductivity of blending solution could be improved by the addition of ethanol which increased the splitting of the jet and decreased the numbers of beads.