| 阿昔洛韦在超临界CO2中的溶解度与关联 |
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| 引用本文： | 米娜,蒋斌波,陈纪忠.阿昔洛韦在超临界CO2中的溶解度与关联[J].高校化学工程学报,2005,19(1):1-4. |
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| 作者姓名： | 米娜 蒋斌波 陈纪忠 |
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| 作者单位： | 浙江大学,化学工程与生物工程学系,浙江,杭州,310027;浙江大学,化学工程与生物工程学系,浙江,杭州,310027;浙江大学,化学工程与生物工程学系,浙江,杭州,310027 |
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| 摘 要： | 药物微粒化可改善其溶出度，提高生物利用度。为应用超临界流体技术制备阿昔洛韦(Acyclovir)微粒，用静态法测定了在313．15～413．15K，10．0～30．0MPa下阿昔洛韦在超临界CO2中的溶解度。阿昔洛韦的溶解度较小，在10^-5～10^-7(摩尔分率)之间，溶解度随着温度和压力的升高而增大，不存在文献报道的反向区。采用P-R方程对溶解度数据进行关联，平均相对误差为10．0％。
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| 关 键 词： | 阿昔洛韦 超临界流体 溶解度 模型 |
| 文章编号： | 1003-9015(2005)01-0001-04 |
| 修稿时间： | 2003年11月11 |
Solubility of Acyclovir in Supercritical Carbon Dioxide |
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| MI Na,JIANG Bin-bo,CHEN Ji-zhong.Solubility of Acyclovir in Supercritical Carbon Dioxide[J].Journal of Chemical Engineering of Chinese Universities,2005,19(1):1-4. |
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| Authors: | MI Na JIANG Bin-bo CHEN Ji-zhong |
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| Abstract: | The micronization of drug can improve its dissolvability and enhance its bioavailability. In order to produce Acyclovir micro particles by using supercritical fluid technology, the solubility of Acyclovir in supercritical CO2 was measured under temperature of 313.15~413.15K and pressure of 10.0~30.0 MPa by static state method. It was found that Acyclovir has low solubility (10?5~10?7 , mol?mol?1) in supercritical CO2 and the solubility increases with the increasing of pressure and temperature. No retrograde area was found which was reported in some references. P-R equation can correlate the experimental data of Acyclovir solubility satisfactorily, and the average relative deviation is 10.0%. |
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| Keywords: | Acyclovir supercritical fluid solubility model |
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