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On the Physical Meaning of the Isothermal Titration Calorimetry Measurements in Calorimeters with Full Cells |
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| Authors: | Jean-Pierre E. Grolier Jose Manuel del R��o |
| Affiliation: | 1. Laboratoire de Thermodynamique des Solutions et des Polymères Université Blaise Pascal, 24, Avenue des Landais, Clermont Ferrand, 63177 Aubière Cedex, France; E-Mail: (J.-P.E.G.);2. Research and Development Branch on Flow Assurance, Mexican Institute of Petroleum, Eje Central Lazaro Cardenas 152, Col. San Bartolo Atepehuacan, Mexico City 07730, Mexico |
| Abstract: | We have performed a detailed study of the thermodynamics of the titration process in an isothermal titration calorimeter with full cells. We show that the relationship between the enthalpy and the heat measured is better described in terms of the equation Δ H = Winj + Q (where Winj is the work necessary to carry out the titration) than in terms of ΔH = Q. Moreover, we show that the heat of interaction between two components is related to the partial enthalpy of interaction at infinite dilution of the titrant component, as well as to its partial volume of interaction at infinite dilution. |
| Keywords: | isothermal titration calorimetry ITC calorimetry thermodynamics infinite dilution binding partial properties enthalpy heat |