小米酸不溶性蛋白抗四氯化碳肝损伤的研究

研究小米酸不溶性蛋白对CCl4所致小鼠肝损伤动物模型的保肝作用。结果显示：小米酸不溶性蛋白处理组与肝损伤对照组相比，小米酸不溶性蛋白处理组的动物血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)水平及肝组织中丙二醛(MDA)含量显著降低(P＜0.05)，并且，小鼠肝脏表面形态异常症状减轻，小米酸不溶性蛋白处理组的肝细胞坏死、脂肪变性和炎性细胞浸润等病变较少，其中小米酸不溶性蛋白高剂量组的效果最佳。结果表明，小米酸不溶性蛋白对CCl4所致动物急性肝损伤具有保护作用。

Protective Effect of Acid-insoluble Protein from Millet against CCl4-induced Liver Injury in Mice

In this paper, the protective effect of acid-insoluble protein from millet against CCl4-induced liver injury in mice was explored. The results indicated that serum ALT and AST levels and hepatic MDA content in mice treated with acid-insoluble protein from millet were significantly lower than those in mice from the liver damage model group (P <0.05). Meanwhile, abnormal morphology of mouse liver surface, necrosis of liver cells, steatosis and inflammatory cells infiltration were reduced by dietary administration with acid-insoluble protein from millet in a dose-dependent manner. Therefore, millet acid insoluble protein can protect mice from acute liver injury induced by CCl4.