Specific features of deuterium and tritium labeling of SB258585

Samples of SB258 585 labeled with hydrogen isotopes were synthesized. ²H]SB258 585 containing one ²H atom per molecule and ³H]SB258585 with the molar radioactivity of 15 Ci mmol^?1 were obtained in preparative amounts. From 0.18 to 1.5 ²H atoms were incorporated, on the average, into an SB 258 585 molecule depending on the reaction conditions. The isotope exchange efficiency strongly depends not only on the catalyst-substrate ratio and on the reaction temperature, but also on processes occurring on the support surface. The isotope effects strongly influence the degree of deuterium or tritium incorporation into the samples in cases when the organic compound largely decomposes in the course of the reaction.