| Synthesis, characterization and antitumor activity of rare earth （Y, La） substituted phosphotungstates containing 5-fluorouracil |
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| 引用本文： | 刘霞,甘强,冯长根.Synthesis, characterization and antitumor activity of rare earth （Y, La） substituted phosphotungstates containing 5-fluorouracil[J].中国稀土学报(英文版),2012,30(6):604-608. |
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| 作者姓名： | 刘霞 甘强 冯长根 |
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| 作者单位： | [1]College of Science, China Agricultural University, Beijing 100193, China [2]School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China |
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| 基金项目： | Foundation item： Project supported by Institution of Chemical Materials, China Academy of Engineering Physics |
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| 摘 要： | Two rare earth substituted Keggin-type phosphotungstates containing 5-fluorouracil,K10C4H4FN2O2Y(PW11O39)2·10H2O(FYPW) and K9(C4H4FN2O2)2La(PW11O39)2·18H2O(FLaPW)were synthesized in aqueous solution,and the structures were characterized by Fourier transform infrared spectroscopy(FT-IR),element analysis,inductively coupled plasma spectrometry(ICP),X-ray powder diffraction(XRD) and 1 H nuclear magnetic resonance(NMR).Thermal analysis showed that the decomposition processes of the two compounds could be divided into three steps,the loss of crystal water,the decomposition of 5-fluorouracil unit and the decomposition of Keggin-type polyanions. The in vitro cytotoxicities against HEK 293,HeLa and HepG-2 cells were studied by methyl thiazolyl tetrazolium(MTT)assay.The results showed that FYPW and FLaPW had higher antitumor activities than 5-fluorouracil,C4H4FN2O2H2PW12O40·8H2O and rare earth substituted polyoxometalates K11Ln(PW11O39)2·nH2O(Ln=Y,La).It was concluded that introducing 5-fluorouracil and rare earth(Y or La)into its structure was a considerable way to enhance antitumor activities of polyoxometalates.
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| 关 键 词： | phosphotungstates 5-flurouracil rare earth cytotoxicity antitumor HeLa HepG-2 |
| 收稿时间： | 17 October 2011 |
Synthesis, characterization and antitumor activity of rare earth （Y, La） substituted phosphotungstates containing 5-fluorouracil |
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| LIU Xia,GAN Qiang,FENG Changgen.Synthesis, characterization and antitumor activity of rare earth （Y, La） substituted phosphotungstates containing 5-fluorouracil[J].Journal of Rare Earths,2012,30(6):604-608. |
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| Authors: | LIU Xia GAN Qiang FENG Changgen |
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| Affiliation: | 1.College of Science,China Agricultural University,Beijing 100193,China;2.School of Mechatronical Engineering,Beijing Institute of Technology,Beijing 100081,China) |
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| Abstract: | Two rare earth substituted Keggin-type phosphotungstates containing 5-fluorouracil,K10C4H4FN2O2Y(PW11O39)2·10H2O(FYPW) and K9(C4H4FN2O2)2La(PW11O39)2·18H2O(FLaPW)were synthesized in aqueous solution,and the structures were characterized by Fourier transform infrared spectroscopy(FT-IR),element analysis,inductively coupled plasma spectrometry(ICP),X-ray powder diffraction(XRD) and 1 H nuclear magnetic resonance(NMR).Thermal analysis showed that the decomposition processes of the two compounds could be divided into three steps,the loss of crystal water,the decomposition of 5-fluorouracil unit and the decomposition of Keggin-type polyanions. The in vitro cytotoxicities against HEK 293,HeLa and HepG-2 cells were studied by methyl thiazolyl tetrazolium(MTT)assay.The results showed that FYPW and FLaPW had higher antitumor activities than 5-fluorouracil,C4H4FN2O2H2PW12O40·8H2O and rare earth substituted polyoxometalates K11Ln(PW11O39)2·nH2O(Ln=Y,La).It was concluded that introducing 5-fluorouracil and rare earth(Y or La)into its structure was a considerable way to enhance antitumor activities of polyoxometalates. |
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| Keywords: | phosphotungstates 5-flurouracil rare earth cytotoxicity antitumor HeLa HepG-2 |
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