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Stereological estimation of the total volume of MR visible brain lesions in patients with multiple sclerosis |
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| Authors: | Neil Roberts Silas Barbosa Lance D Blumhardt Ron A Kawoski Richard H T Edwards |
| Affiliation: | (1) Magnetic Resonance Research Centre, University of Liverpool, P.O. Box 147, L69 3BX Liverpool, UK;(2) Faculty of Medicine, Queens Medical Centre, Division of Clinical Neurology, NG7 2UH Nottingham, UK;(3) Department of Physiology and Biophysics, Mayo Foundation, Biomedical Imaging Resource, 55905 Rochester, Minnesota, USA |
| Abstract: | Point counting represents a convenient and efficient technique for estimating the area of transects through multiple sclerosis (MS) lesions on magnetic resonance (MR) images obtained for sections through the brain. When sectioning has been performed according to the Cavalieri method, unbiased estimates of the total volume of MR-visible MS plaques can be obtained with a precision of 3–5% in 5–10 min. |
| Keywords: | MRI Matheron formula multiple sclerosis nugget effect point counting stereology volume |
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