| 2,4,5-三氟苯乙酸的合成 |
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| 引用本文： | 何人宝,王莺妹,金逸中,俞传明.2,4,5-三氟苯乙酸的合成[J].化工生产与技术,2011,18(3):4-6,69. |
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| 作者姓名： | 何人宝 王莺妹 金逸中 俞传明 |
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| 作者单位： | 1. 浙江永太科技股份有限公司,浙江临海,317016
2. 浙江工业大学,杭州,310014 |
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| 基金项目： | 浙江省科技厅科技计划重大项目 |
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| 摘 要： | 以1,2,4-三氟苯为原料,经氯甲基化、羰基化、水解制得2,4,5-三氟苯乙酸,对原料配比、温度、催化剂用量等因素进行了考察,结果表明,优化的反应条件为:合成2,4,5-三氟苄氯时,m(C6H3F3):m(多聚甲醛)=1.0:0.875～0.865,反应时间10 h；合成2,4,5-三氟苯乙酸时,m(C7H4F3Cl)...
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| 关 键 词： | 2 4 5-三氟苯乙酸 羰基化 合成 |
Synthesis of 2,4,5-Trifluorobenacetic Acid |
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| He Renbao,Wang Yingmei,Jin Yizhong,Yu Chuanming.Synthesis of 2,4,5-Trifluorobenacetic Acid[J].Chemical Production and Technology,2011,18(3):4-6,69. |
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| Authors: | He Renbao Wang Yingmei Jin Yizhong Yu Chuanming |
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| Affiliation: | 1.Zhejiang Yongtai Technology Co.,Ltd,Linhai,Zhejiang,317016;2.Zhengjiang University of Technology,Hangzhou 310014) |
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| Abstract: | 2,4,5-Trifluorobenacetic acid was synthesized from 1,2,4-trichlorobenzene via chloromethylation,carbonylation and hydrolyzation.Results show that the optimization synthesis condition of 2,4,5-trifluorobenzyl chloride are as follows: m(C6H3F3):m(paraformaldehyde)=1.0:0.875～0.865,reaction time: 10 h.And the optimization synthesis condition of 2,4,5-trifluorobenacetic acidis m(C7H4F3Cl):m(cat)=1:0.275～0.25 and thereaction temperature is 40 ℃,under this condition,the total yield is above 60%,the purity is above 99%.The proportion of reactants and dosage of catalyst were discussed. |
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| Keywords: | 2 4 5-trifluorobenacetic acid carbonylation synthesis |
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