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Design of Stimuli-Responsive Peptides and Proteins |
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| Authors: | Yang Li Guangze Yang Lukas Gerstweiler San H Thang Chun-Xia Zhao |
| Affiliation: | 1. School of Chemical Engineering and Advanced Materials, Faculty of Sciences, Engineering and Technology, The University of Adelaide, Adelaide, 5005 Australia
Australian Research Council, Centre of Excellence for Enabling Eco-Efficient Beneficiation of Minerals, Adelaide, 5005 Australia Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, 4072 Australia;2. School of Chemical Engineering and Advanced Materials, Faculty of Sciences, Engineering and Technology, The University of Adelaide, Adelaide, 5005 Australia;3. Australian Research Council, Centre of Excellence for Enabling Eco-Efficient Beneficiation of Minerals, Adelaide, 5005 Australia School of Chemistry, Monash University, Melbourne, 3800 Australia |
| Abstract: | Stimuli-responsive peptides and proteins are an exciting class of smart biomaterials for various applications and have received significant attention over the past decades. A wide variety of stimuli such as temperature, pH, ions, enzymes, magnetic field, redox, etc., are explored. This article provides a review of five intensively studied types of stimuli-responsive peptides and proteins, their design principles and applications, including temperature-, pH-, light-, metal ion-, and enzyme-responsive with an emphasis on the key design concepts and switch function. Moreover, typical examples of their applications are discussed to provide a better understanding of the design concept and underlying methodology. This review will facilitate and inspire future innovation toward new peptide- and protein-based materials and their diverse applications. |
| Keywords: | light metal ions peptides pH proteins stimuli-responsive behaviors temperature |