| 喹诺酮化合物5，7-二氨基-1-环丙基-6，8-二氟-1，4-二氢-4-氧代喹啉-3-羧酸的合成研究 |
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| 引用本文： | 张凌霞,黄山.喹诺酮化合物5，7-二氨基-1-环丙基-6，8-二氟-1，4-二氢-4-氧代喹啉-3-羧酸的合成研究[J].江西化工,2009(3):100-103. |
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| 作者姓名： | 张凌霞 黄山 |
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| 作者单位： | |
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| 摘 要： | 研究5，7-二氨基-1-环丙基-6，8-二氟-1，4-二氢-4-氧代喹啉-3-羧酸（1）的合成路线和工艺。原料2，3，4，5-四氟苯甲酸经硝化、酰氯化、缩合，水解脱羧等多步反映得到中间体2，中间体2与叔丁胺亲核取代后，酸水解，氢化还原得到目标化合物。
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| 关 键 词： | 喹诺酮 光毒性 取代反应 水解反应 氢化反应 |
Synthesis of 5,7-diamino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid |
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| ZHANG Ling-xia,HUANG Shan.Synthesis of 5,7-diamino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid[J].Jiangxi Chemical Industry,2009(3):100-103. |
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| Authors: | ZHANG Ling-xia HUANG Shan |
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| Abstract: | The synthetic route and improved process for the preparation of 5,7-diamino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid were studied.Compound 1 was synthesized from itermediate compound 2 via nucleophilic substitution,hydrolyzation and hydrogenation.Itermediate compound 2 was synthesized from 2,3,4,5-tetrafluorobenzoic acid via nitronation,acylchlorination,condensation,hydrolysis and decarboxylation,etc. |
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| Keywords: | fluoroquinolone phototoxicity nucleophilic substitution hydrolyzation hydrogenation |
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