The importance of the steric configuration of lysophosphatidylcholine in the lymphatic transport of fat |
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| Authors: | P. J. A. O'doherty |
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| Affiliation: | (1) G.F. Strong Laboratory for Medical Research, Department of Medicine, University of British Columbia, V5Z 1M9 Vancouver, British Columbia, Canada |
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| Abstract: | The importance of the steric configuration of lysophosphatidylcholine in the lymphatic transport of fat was investigated in
bile fistula rats. It was found that the feeding of 1-palmitoyl-sn-glycero-3-phosphocholine increased the lymphatic output of phosphatidyl choline and triacylglycerol, while the feeding of
3-palmitoyl-sn-glycero-1-phosphocholine had no effect. In intestinal microsomes of the bile fistula rats, it was found that the lysophosphatidylcholine
acyltransferase was stereospecific in acylating the 1-acyl-sn-glycero-3-phosphocholine enantiomer. The significance of these findings is briefly discussed. |
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