| 四正丁基溴化铵催化合成香豆素的研究 |
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| 引用本文： | 王莹莹,王丹,胡清华,陈雯婷,杨廷贤.四正丁基溴化铵催化合成香豆素的研究[J].安徽化工,2011,37(4):26-27. |
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| 作者姓名： | 王莹莹 王丹 胡清华 陈雯婷 杨廷贤 |
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| 作者单位： | 武汉大学东湖分校生命科学与化学学院,湖北武汉,430212 |
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| 摘 要： | 以水杨醛和醋酸酐为原料,无水碳酸钾为催化剂来合成香豆素。研究了四正丁基溴化铵的活化作用、四正丁基溴化铵的用量、反应温度以及反应时间对香豆素产率的影响。结果表明：用四正丁基溴化铵作活化剂,香豆素的产率由原来的61.3%提高到84.3%。最佳反应条件：n（水杨醛）∶n（四正丁基溴化铵）=1∶0.04,反应温度160℃,反应时间4h,香豆素的产率可达85.1%。
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| 关 键 词： | 四正丁基溴化铵 香豆素 无水碳酸钾 |
Synthesis of Coumarin Using a Catalyst Activated by Tetra-butyl Ammonium Bromide |
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| WANG Ying-ying,WANG Dan,HU Qing-hua,CHEN Wen-ting,YANG Ting-xian.Synthesis of Coumarin Using a Catalyst Activated by Tetra-butyl Ammonium Bromide[J].Anhui Chemical Industry,2011,37(4):26-27. |
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| Authors: | WANG Ying-ying WANG Dan HU Qing-hua CHEN Wen-ting YANG Ting-xian |
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| Affiliation: | (College of Life Science & Chemistry,Donghu College,Wuhan University,Wuhan 430212,China) |
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| Abstract: | Coumarin was synthesized from salicyl aldehyde and acetic anhydride as raw materials,using anhydrous potassium carbonate as catalyst.The activation and dosage of tetra-butyl ammonium bromide and temperature and time of reaction were studied.Results showed that the yield of coumarin is up to 84.3% from 61.3% using tetra-butyl ammonium bromide as activating agent.The best molar rate of salicyl aldehyde and tetra-butyl ammonium bromide is 1 ∶ 0.04 and final reaction temperature is 160℃ and the best time is 4h.Overall yield of Coumarin achieves 85.1%. |
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| Keywords: | tetra-butyl ammonium bromide coumarin anhydrous potassium carbonate |
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