木二糖对营养性肥胖大鼠的减肥作用

目的:建立营养性肥胖大鼠模型,研究木二糖对大鼠血脂、血糖和脂肪堆积情况的影响。方法:选取雄性SD大鼠62只,分为正常对照组10只,给予普通饲料喂养,随机选取造模成功的44只分为低剂量木二糖组(200 mg/(kg·d))、高剂量木二糖组(400 mg/(kg·d))、阳性对照组(盐酸西布曲明4 mg/(kg·d))和模型对照组,每组11只,给予高糖高脂饮食,连续喂养80 d,在20、40、60、80d分别检测各项指标。结果:各处理组大鼠比模型组体质量有明显降低(P0.01);喂养60~80 d,各处理组血糖值与正常对照组无显著性差异,显著低于模型对照组(P0.01);各处理组均能显著降低大鼠血清甘油三酯与低密度脂蛋白胆固醇(P0.01),但对大鼠血清胆固醇与高密度脂蛋白胆固醇无影响。喂养80d后处死大鼠,测得各处理组大鼠Lee’s指数与模型对照组均有显著性差异(P0.01),脂肪湿质量和体脂比亦有差异,且呈量效关系。结论:木二糖对营养性肥胖大鼠具有较好的降血糖、降血脂作用,可有效抑制大鼠体内脂肪堆积。

Anti-Obesity Effects of Xylobiose on Diet-Induced Obese Rats

Objective: The effects of xylobiose on blood fat, blood sugar and fat accumulation of diet-induced obese rats were
studied. Methods: Totally 62 male SD rats were chosen in this study, in which 10 rats in the control group received normal
feed, and 44 rats in the model group were randomized into low-dose xylobiose group (200 mg/(kg·d)), high-dose xylobiose
group (400 mg/(kg·d)) and positive control group (sibutramine hydrochloride with 4 mg/(kg·d)) and model control group
with 11 animals each, all of which received high sugar and high fat diet for 80 continuous days. Serum and body indexes
were tested on the 20th, 40th, 60th and 80th day. Results: The body weights of rats in the administration groups were decreased
compared with the model group (P ＜ 0.01); on the 60th and 80th days, blood sugar values were insignificantly different
from those of the control group, but lower than those of the model control group significantly (P ＜0.01). TG and LDL-C
levels decreased in all the administration groups compared with the model control group (P ＜0.01), but without effects
on LC or HDL-C. The Lee’s indexes of sacrificed rats in the administration groups were significantly different compared
with the model group after feeding for 80 days, as well as the ratio of wet weight of fat pad to body fat which had doseeffect
relationship. Conclusion: Xylobiose can reduce the blood sugar and blood fat and inhibit the fat accumulation of dietinduced
obese rats.