党参、白芨、制大黄及其配伍抗大鼠实验性胃溃疡作用

目的 观察党参、白芨、制大黄及其配伍对实验性大鼠胃溃疡的作用。方法 采用无水G醇致胃 粘膜损伤, 幽门结扎诱发胃溃疡和乙S交诱发慢性胃溃疡三种模型, 观察党参、白芨、制大黄及配伍 对溃疡、指数胃分泌、胃壁粘液量和胃粘膜血流量的影响。结果与结论 三药及其配伍均不同程 度地降低了三种模型的溃疡指数, 复方疗效好于党参；且三药及其复方不同程度地增加了胃壁粘 液分泌量和胃粘膜血流量。影响胃壁粘液分泌和胃粘膜血流量可能是其作用的原因之一。

Effects of codonopsis pilosula,bletilla striata prepared rheum palmatum and their formuia on Experimental ulcer models in rats

Aim and Methods Effects of codonoposis pilosula, bletilla, striata prepared rheum palmaturn and their formula respectively on experimental ulcer model induced by ethanol, ulcer model induced by pylorus-ligation and chronic ulcer model induced by ethanoic acid in rats were observed, and the amount of gastric secretion, gastric mucus and mucosa blood flow was also determined to provide clues to evaluation of their effects. Result The results showed that the drugs and their formula respectively decreased the idexes of ulcer in different models to varying degree, and that they increased the amount of gastric mucus and gastric muscosa blood flow. Conclusion Drugs have better cruative effect for gastric ulcer, and the effect may partly result from their influences on the mucus secretion and gastric mucosa blood flow.