性激素类药物诱发胆囊结石的实验研究

目的 探索性激素类药物诱发胆囊结石的关系。方法 用大白免60只,分6组,给予雌二醇、孕酮、睾酮、绒毛膜促性腺激(HCG),ip, 设生理盐水和精茶油对照组。实验时间6周,处死检测血液、胆汁、胆囊、胆管、肝脏及胆石。结果 雌二醇组90%成石; HCG组内雌性兔100%成石,雄性兔无结石形成;孕酮组无结石,睾酮组仅1例胆囊结石,两对照组均无结石。成石为胆固醇性结石。结论 性激素类 药物中,雌二醇、HCG与胆囊胆固醇结石的形成有关。

The experimental study on forming of gallstone induced by drugs of sex hormone

Aim To know whether the sex hormone played a role in formation of gallstone, the experimental study on the drugs was designed. Methods 60 rabbits were randomly divided into 6 groups in 4 of which(groups E₂,P,T,H) estradiol,progesterone,testosterone and HCG were administered separately, and normal saline and refined oil were given to as control in the other groups(C₁、C₂). The animals were put to death in 6 weeks. The blood, bite, gallbladder, bile duct, liver and gallstones were assayed. Results The gallstone formation rate was 90% in group E₂,50% in group H and 10% in group T. There no gallstone that was formed in the alimals in groups P, C₁ and C₂. Most of the gallstones were found in the female animals. Only in group E₂ were the gallstones found in 4 male rabbits. The comnpostion of stone was mainly choles-terol. Conclusion Among the sex hormones estradiol and HCG are in relation to the formation of gallbladder cholestrol stone.