| Fibroblast Adhesion and Proliferation on a New β Type Ti-39Nb-13Ta-4.6Zr Alloy for Biomedical Application |
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| 作者姓名： | Yongkang ZHAO Yang YAO Weixian LIU Caiyun ZHENG Shujun LI |
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| 作者单位： | [1]The Second Affiliated Hospital, China Medical University, Shenyang 110004, China [2]Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China |
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| 基金项目： | This work was supported by the Scientific Research Program of Education Department of Liaoning Province （No.202013122） |
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| 摘 要： | Cell attachment and spreading on Ti-based alloy surfaces is a major parameter in implant technology. Ti-39Nb-13Ta-4.6Zr alloy is a new β type Ti alloy developed for biomedical application. This alloy has low modulus and high strength, which indicates that it can be used for medical purposes such as surgical implants. To evaluate the biocompatibility and effects of the surface morphology of Ti-39Nb-13Ta-4.6Zr on the cellular behaviour, the adhesion and proliferation of rat gingival fibroblasts were studied with substrates having different surface roughness and the results were also compared with commercial pure titanium and Ti-6Al-4V. The results indicate that fibroblast shows similar adhesion and proliferation on the smooth surfaces of commercial pure titanium （Cp Ti）, Ti-39Nb-13Ta-4.6Zr, and Ti-6Al-4V, suggesting that Ti-39Nb-13Ta-4.6Zr has similar biocompatibility to Cp Ti and Ti-6Al-4V. The fibroblast adhesion and spreading was lower on rough surfaces of Cp Ti, Ti-39Nb-13Ta-4.6Zr and Ti-6Al-4V than on smooth ones. Surface roughness appeared to be a dominant factor that determines the fibroblast adhesion and proliferation.
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| 关 键 词： | 生物医学材料 钛铌钽锆合金 Ti-39Nb-13Ta-4.6Zr 纤维原细胞 表面粗糙度 |
| 收稿时间： | 2005-07-13 |
| 修稿时间： | 2005-11-21 |
Fibroblast Adhesion and Proliferation on a New β Type Ti-39Nb-13Ta-4.6Zr Alloy for Biomedical Application |
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| Yongkang ZHAO Yang YAO Weixian LIU Caiyun ZHENG Shujun LI.Fibroblast Adhesion and Proliferation on a New β Type Ti-39Nb-13Ta-4.6Zr Alloy for Biomedical Application[J].Journal of Materials Science & Technology,2006,22(2):205-210. |
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| Authors: | Yongkang ZHAO Yang YAO Weixian LIU Caiyun ZHENG Shujun LI |
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| Affiliation: | The Second Affiliated Hospital, China Medical University, Shenyang 110004, China; Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China |
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| Abstract: | Cell attachment and spreading on Ti-based alloy surfaces is a major parameter in implant technology. Ti-39Nb-13Ta-4.6Zr alloy is a new β type Ti alloy developed for biomedical application. This alloy has low modulus and high strength, which indicates that it can be used for medical purposes such as surgical implants. To evaluate the biocompatibility and effects of the surface morphology of Ti-39Nb-13Ta-4.6Zr on the cellular behaviour, the adhesion and proliferation of rat gingival fibroblasts were studied with substrates having different surface roughness and the results were also compared with commercial pure titanium and Ti-6Al-4V. The results indicate that fibroblast shows similar adhesion and proliferation on the smooth surfaces of commercial pure titanium (Cp Ti), Ti-39Nb-13Ta-4.6Zr, and Ti-6Al-4V, suggesting that Ti-39Nb-13Ta-4.6Zr has similar biocompatibility to Cp Ti and Ti-6Al-4V. The fibroblast adhesion and spreading was lower on rough surfaces of Cp Ti, Ti-39Nb-13Ta-4.6Zr and Ti-6Al-4V than on smooth ones. Surface roughness appeared to be a dominant factor that determines the fibroblast adhesion and proliferation. |
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| Keywords: | Biomaterials Titanium alloys Fibroblast Adhesion Proliferation Surface roughness |
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