| 介孔生物活性玻璃装载和释放抗癌药物表阿霉素的研究 |
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| 引用本文： | 周艳玲,冯新星,翟万银,常江. 介孔生物活性玻璃装载和释放抗癌药物表阿霉素的研究[J]. 无机材料学报, 2011, 26(1): 68-72. DOI: 10.3724/SP.J.1077.2011.00068 |
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| 作者姓名： | 周艳玲 冯新星 翟万银 常江 |
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| 作者单位： | 中国科学院 上海硅酸盐研究所, 上海 200050 |
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| 基金项目： | 国家重点基础研究发展973计划(2005cB522704); 国家自然科学基金(30730034); 上海市基础研究重点项目(08JC1420800); 国家高技术研究发展863计划(2007AA032317)~~ |
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| 摘 要： | 将介孔58S生物活性玻璃(m58S)作为抗癌药物载体评价了其对表阿霉素的装载量和释放性能. 实验结果表明, m58S对亲水性药物表阿霉素的药物装载量为40%, 是普通溶胶-凝胶58S生物活性玻璃的3倍多, 并且具有更长效的缓释特性. 研究还发现释放介质的pH值对表阿霉素的释放速率有很大影响, pH值越低, 表阿霉素分子从载体材料中释放出的速率越快. 因此, 介孔生物活性玻璃是一种高效的药物缓释载体, 且药物释放速率受释放介质pH值影响, 有望成为药物控释型骨修复材料.
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| 关 键 词： | 生物活性玻璃 介孔材料 药物载体 |
| 收稿时间： | 2010-04-10 |
| 修稿时间： | 2010-05-21 |
Study on the Loading and Releasing Behavior of Epirubicin Hydrochloride from Mesoporous Bioactive Glasses(MBGs) |
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| ZHOU Yan-Ling,FENG Xin-Xing,ZHAI Wan-Yin,CHANG Jiang. Study on the Loading and Releasing Behavior of Epirubicin Hydrochloride from Mesoporous Bioactive Glasses(MBGs)[J]. Journal of Inorganic Materials, 2011, 26(1): 68-72. DOI: 10.3724/SP.J.1077.2011.00068 |
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| Authors: | ZHOU Yan-Ling FENG Xin-Xing ZHAI Wan-Yin CHANG Jiang |
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| Affiliation: | Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China |
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| Abstract: | Mesoporous bioactive glasses m58S were loaded with an anticancer drug-Epirubicin hydrochloride(EPI) and the release of the drug from the glasses was evaluated.The drug loading capacity of m58S for EPI was 40%, which was three times higher than that of conventional Sol-Gel bioactive glasses 58S.In phosphate buffered saline (PBS),the m58S-EPI system showed a sustained release behavior.Furthermore,the release rates from the EPI-m58S system increased with the decrease of pH values of the release medium.The resu... |
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| Keywords: | bioactive glasses mesoporous materials drug delivery system |
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