Synthese von N-Maleoyl-aminosäuren und -peptiden

Synthesis of N-Maleoyl-aminoacids and -peptides N-Maleoyl-aminoacid-N′-hydroxysuccinimidesters 3 or N-maleoyl-aminobenzoic acids 5 are synthesized from N-maleyl-aminoacids 1 on different ways. N-maleoyl-aminobenzoic-4-nitro-phenyl-,-2-nitro-phenyl-or 2,4-dinitro-phenylesters 6 , 7 and 8 will be obtained from 1 or 5 . o-Mercapto-aniline, thiourea or cysteine react with 5 to benzothiazines 9 , thiazolidines 10 and 1,4-thiazines 11 . from 5 the peptides 12 are yielded. The pentapeptide 13 are formed from 12 by addition of glutathione.