Metabolic Syndrome: Effects of n-3 PUFAs on a Model of Dyslipidemia,Insulin Resistance and Adiposity |
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Authors: | Yolanda B Lombardo Gustavo Hein Adriana Chicco |
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Affiliation: | (1) Department of Biochemistry, School of Biochemistry, University of Litoral, Ciudad Universitaria Paraje “EL Pozo”.C.C.242 (3000), Santa Fe, Argentina |
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Abstract: | Both genetic and environmental factors (e.g. nutrition, life style) contribute to the development of the plurimetabolic syndrome,
which has a high prevalence in the world population. Dietary n-3 PUFAs specially those from marine oil (EPA and DHA) appear
to play an important role against the adverse effects of this syndrome. The present work examined the effectiveness of fish
oil (FO) in reversing or improving the dyslipidemia, insulin resistance and adiposity induced in rats by long-term feeding
a sucrose-rich diet (SRD). We studied several metabolic and molecular mechanisms involved in both lipid and glucose metabolisms
in different tissues (liver, skeletal muscle, fat pad) as well as insulin secretion patterns from perifused islets under the
stimulation of different secretagogues. Dietary FO reverses dyslipidemia and improves insulin action and adiposity in the
SRD fed rats. FO reduces adipocytes cell size and thus, the smaller adipocytes are more insulin sensitive and the release
of fatty acids decreases. In muscle, FO normalizes both the oxidative and non-oxidative glucose pathways. Moreover, FO modifies
the fatty acid composition of membrane phospholipids. In isolated β cells, lipid contents and glucose oxidation return to
normal. All these effects could contribute to the normalization of glucose-stimulated insulin secretion and muscle insulin
insensitivity. |
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Keywords: | n-3 PUFAs Metabolic syndrome Sucrose-rich diet Dyslipidemia Insulin resistance Visceral adiposity |
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