| (R)-2-芳基-4-羟甲基-1,3-(噁)唑啉类化合物的合成 |
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| 引用本文： | 卢君,沈振陆,莫卫民.(R)-2-芳基-4-羟甲基-1,3-(噁)唑啉类化合物的合成[J].化学试剂,2007,29(6):355-357. |
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| 作者姓名： | 卢君 沈振陆 莫卫民 |
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| 作者单位： | 浙江工业大学,化学工程与材料学院,浙江,杭州,310014 |
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| 基金项目： | 浙江省自然科学基金资助项目(Y404058) |
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| 摘 要： | 以L-丝氨酸甲酯盐酸盐和芳基甲腈类化合物为原料,经亚胺化、环合、还原3步反应合成了标题化合物。产物结构经IR、MS和1HNMR确证。实验结果表明,在乙醇溶剂中,NaBH4能把(S)-2-芳基-4-甲酯基-1,3-噁唑啉类化合物中的酯基有效地还原为羟甲基。
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| 关 键 词： | L-丝氨酸甲酯盐酸盐 芳基甲腈 2-芳基-4-羟甲基-1 3-噁唑啉 NaBH4 |
| 文章编号： | 0258-3283（2007）06-0355-03 |
| 修稿时间： | 2006-11-05 |
Synthesis of ( R )-2-aryl-4-hydroxymethyl-1,3-oxazolines |
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| LU Jun,SHEN Zhen-lu,MO Wei-min.Synthesis of ( R )-2-aryl-4-hydroxymethyl-1,3-oxazolines[J].Chemical Reagents,2007,29(6):355-357. |
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| Authors: | LU Jun SHEN Zhen-lu MO Wei-min |
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| Affiliation: | College of Chemical Engineering and Material Science, Zhejiang University of Technology, Hangzhou 310014, China |
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| Abstract: | (R)-2-aryl-4-hydroxymethyl-1,3-oxazolines were synthesized from L-serine methyl ester hydrochloride and aryl cyanides in three steps,including imidization,cyclization and reduction.Their structures were confirmed by IR,MS and 1HNMR.The experimental results showed that(S)-2-aryl-4-carbomethoxy-1,3-oxazolines could be reduced to(R)-2-aryl-4-hydroxymethyl-1,3-oxazolines effectively with NaBH4 in ethanol. |
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| Keywords: | L-serine methyl ester hydrochloride aryl cyanides (R)-2-aryl-4-hydroxymethyl-1 3-oxazolines NaBH4 |
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