| 1,4-二(溴甲基)-2-氟苯的合成工艺改进 |
| |
| 引用本文： | 何卫华,陆明,贺鹰,宋艳民.1,4-二(溴甲基)-2-氟苯的合成工艺改进[J].化学试剂,2007,29(7):441-442. |
| |
| 作者姓名： | 何卫华 陆明 贺鹰 宋艳民 |
| |
| 作者单位： | 南京理工大学,化工学院,江苏,南京,210094 |
| |
| 摘 要： | 以对二甲苯为原料,经硝化、还原、重氮化、溴代4步反应得到标题化合物。其中溴代反应中,1,4-二甲基-2-氟苯在偶氮二异丁腈(AIBN)引发下与N-溴代丁二酰亚胺(NBS)发生自由基反应。总收率达到30%,其结构经1HNMR和GC/MS确证。
|
| 关 键 词： | 1 4-二(溴甲基)-2-氟苯 对二甲苯 合成 |
| 文章编号： | 0258-3283（2007）07-0441-02 |
| 修稿时间： | 2007-01-19 |
Improved synthesis of 1,4-bis(bromomethyl)-2-fluorobenzene |
| |
| HE Wei-hua,LU Ming,HE Ying,SONG Yan-min.Improved synthesis of 1,4-bis(bromomethyl)-2-fluorobenzene[J].Chemical Reagents,2007,29(7):441-442. |
| |
| Authors: | HE Wei-hua LU Ming HE Ying SONG Yan-min |
| |
| Affiliation: | School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China |
| |
| Abstract: | 1,4-Bis(bromomethyl)-2-fluorobenzene was obtained by using p-xylene as the starting material via a four-step reaction involving nitration,reduction,diazotization and bromination with N-bromosuccinimide(NBS).Radical bromi-nation of 1,4-dimethyl-2-fluorobenzene was carried out using NBS in the presence of azobisisiobutyronitrile(AIBN) as the initiator.The overall yield reached 30%,the structure was confirmed by 1HNMR and GC/MS. |
| |
| Keywords: | 1 4-bis(bromomethyl)-2-fluorobe-zene p-xylene synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
