Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications |
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| Authors: | Yingjun Wang Xuetao Shi Li Ren Chunming Wang Dong-An Wang |
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| Affiliation: | aSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, PR China;bDivision of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 637457 Singapore;cKey Laboratory of Specially Functional Materials and Advanced Manufacturing Technology, South China University of Technology, Ministry of Education, Guangzhou 510641, PR China |
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| Abstract: | In this paper, a new route to preparing porous poly (lactic-co-glycolide) (PLGA) scaffolds for bone tissue repair applications was developed. Novel porous PLGA scaffolds were fabricated via microsphere sintered technique and gas forming technique. Ammonium bicarbonate was used to regulate porosity of these porous scaffolds. Porosity of the scaffolds, and cell attachment, viability and proliferation on the scaffolds were evaluated. The results indicated that PLGA porous scaffolds were with the porosity from around 30% to 95% by regulating ammonium bicarbonate content from 0 to 10%. We also found that PLGA porous microsphere scaffolds benefited cell attachment and viability. Taken together, the achieved porous scaffolds have controlled porosity and also support mesenchymal stem cell proliferation, which could serve as potential scaffolds for bone repair applications. |
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| Keywords: | Poly (lactic-co-glycolide) Scaffold Porous Microsphere |
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