高分子材料表面固定生物分子的光化学方法

综述了在高分子材料表面固定生物分子以增强其生物医学应用性能的光化学方法,该方法适用的生物分子有蛋白质和白蛋白,多糖类如肝素,其它如酶,抗体,多肽类,DNA片段等。此方法不会影响高分子材料的本位性能,可基本保持所固定的生物分子的活性,还可以设计材料表面改性区域,经改性的高分子材料可获得良好的生物相容性和多种优良的生物医学应用性能。

The Photochemical Methods of Immobilization Biomolecules on Polymer Materials

This review summarizes several photochemical methods of immobilization biomolecules on polymer materials in order to enhance its biomedical performance. Proteins such as albumin, polysaccharides such as heparin, other biomolecules such as enzyme, antibody, peptides, DNA fragments and so on are all available by those methods. It can retain the reactivity of immobilized biomolecules and do district designed modification without undermining the substrate performance. Polymer materials immobilized with biomolecules can obtain favorable biocompatibility and biomedical performance.