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| 可控降解抗感染材料的合成和表征 | |
| 引用本文： | 李春艳,出端艳,单丽,温志国,黄剑华,董声雄,丁马太. 可控降解抗感染材料的合成和表征[J]. 功能材料, 2010, 41(4) |
| 作者姓名： | 李春艳 出端艳 单丽 温志国 黄剑华 董声雄 丁马太 |
| 作者单位： | 1. 福建医科大学,药学院,福建,福州350108 2. 福州大学,化学化工学院,福建,福州,350108 3. 厦门大学,材料学院,福建,厦门,361005 |
| 基金项目： | 福建省科技厅国际合作处重点资助项目(2006I0019);;福建省科技厅资助省属高校资助项目(2008F50502) |
| 摘 要： | 在聚己内酯(PCL)与六亚甲基二异氰酸酯(HDI)缩合体系中加入抗菌药物环丙沙星(CF),制备CF嵌入聚氨酯(PU)主链的聚氨酯前药CFPU。用UV、FTIR、H-NMR表征其结构;GPC法测定分子量;UV法测定载药率;摸索影响其分子量和载药率的主要因素;并用琼脂稀释法测定其胆固醇酯酶(CE)降解液对金黄色葡萄球菌的抗菌活性。结果表明,确已成功制得目标产物;PCL浓度和HDI加料方式分别对其平均分子量和载药率有较大影响;而其CE降解液对金黄色葡萄球菌具有抗菌活性。因此,当其用作医用内植物的涂层材料时,能被炎症组织所分泌的CE可控降解为这种具抗菌活性的降解液,从而可发挥抗感染作用。 |
| 关 键 词： | 环丙沙星 聚氨酯 高分子前药 可控降解 抗感染 |
Synthesis and characterization of antimicrobial material controlled degradation |
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| LI Chun-yan,CHU Duan-yan,SHAN Li,WEN Zhi-guo,HUANG Jian-hua,DONG Sheng-xiong,DING Ma-tai. Synthesis and characterization of antimicrobial material controlled degradation[J]. Journal of Functional Materials, 2010, 41(4) | |
| Authors: | LI Chun-yan CHU Duan-yan SHAN Li WEN Zhi-guo HUANG Jian-hua DONG Sheng-xiong DING Ma-tai |
| Affiliation: | 1.Faculty of Pharmacy;Fujian Medical University;Fuzhou 350108;China;2.Faculty of Chemical & Engineering;Fuzhou University;3.Faculty of Material;Xiamen University;Xiamen 361005;China |
| Abstract: | Polyurethane prodrug(CFPU),was synthesized via polyurethane condensation reaction,with polycarprolactone(PCL) as soft-segment,1,6-hexane diisocyanate(HDI) as hard-segment and an antibiotics drug,ciprofloxacin(CF).The structure of CFPU was characterized by UV,FTIR,H-NMR,the molecular weight was determined through the method of GPC,the drug-loading rate was determined by UV.The influence factors of molecular weight and drug-loading rate were studied.The antibacterial activity of prodrug degradation solution t... |
| Keywords: | ciprofloxacin polyurethane polymer prodrug controlled degradation antimicrobial |
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