一种用于集成电化学生物传感阵列的高灵敏度 读出电路的研究

一种用于自组装膜生物传感阵列的高灵敏度信号读出电路包含一个高灵敏度电流读出放大器,可以接受pA-nA范围的输入电流,其电流增益大约60 dB,相位裕度为63°,并在同一输入电流信号的条件下,负载在一个较大的范围变化时,其输出电流几乎几乎是一个常数.芯片采用1.2μm CMOS工艺加工,测试结果表明,该芯片的输出电流对输入电流具有较好的线性度.这种新型电路与标准CMOS工艺兼容,可实现集成的生物传感阵列.

Study of a High Sensitive Readout Circuit for Integrated Electrochemical Biosensor Arrays

This paper presents a high sensitive interface circuit that is tuned to the needs of self-assembly biosensor arrays. The circuit includes a high sensitive amperometric readout amplifier. It can accept very weak input current in a pA-nA range, its current gain is about 60dB, phase margin is 63deg, and in the condition of the sane input current signal, the output current of the circuit is almost a constant when the load changed in a larger range. The chip has been fabricated in a 1.2um CMOS process, and the test results showed the output current has a good linearity with the input current. The new circuit is compatible with a standard CMOS process to realize an integrated biosensor array.