Moderate Dietary Intake of Myristic and Alpha-Linolenic Acids Increases Lecithin-Cholesterol Acyltransferase Activity in Humans |
| |
Authors: | Carole Vaysse-Boué Henry Dabadie Evelyne Peuchant Pascale Le Ruyet François Mendy Henry Gin Nicole Combe |
| |
Affiliation: | ITERG, Département de Nutrition, c/o Université Bordeaux 1, Avenue des Facultés, 33405, Talence Cedex, France. |
| |
Abstract: | Cholesterol removal from tissues into HDL depends on the activity of lecithin-cholesterol acyltransferase (LCAT; E.C. 2.3.1.43)
that is associated with lower cardiovascular diseases risk. HDL cholesterol concentration and LCAT activity can be modulated
by dietary fatty acids. Original data with substrate models have shown a positive effect of myristic acid (MA) on the esterification
rate of cholesterol. The purpose of this study was to examine the effect of moderate intakes of MA associated with recommended
intake of alpha-linolenic acid (ALA) on LCAT activity in humans. Two experimental diets were tested for 3 months each. Diet
1-MA 1.2% of total energy (TE) and ALA 0.9% TE, diet 2-MA 1.8% and ALA 0.9% TE; a control diet (MA 1.2% and ALA 0.4% TE) was
given 3 months before diet 1 and diet 2. The endogenous activity of LCAT was determined at completion of each diet. Compared
with the control diet (13.2 ± 3.1 μmol CE/(L.h)), LCAT activity increased significantly (P < 0.001) with diet 1 (24.2 ± 3.6 μmol CE/(L.h)) and diet 2 (33.3 ± 7.4 μmol CE/(L.h)); the increase observed with diet 2
was significantly (P < 0.001) greater than that due to diet 1. These results suggest that ALA (from rapeseed oil, mainly in sn-2 position) and MA (from dairy fat, mainly in sn-2 position) favor LCAT activity, by respective increases of 83 and 38%. When they are supplied together, a complementary
effect was observed (average increase of 152%). Moreover, these observations were associated with a decrease of the ratio
of total to HDL-cholesterol. In conclusion, our results suggest that moderate supply of MA (1.8% TE) associated with the recommended
intake of ALA (0.9% TE) contributes to improve LCAT activity. |
| |
Keywords: | Myristic acid Alpha-linolenic acid sn-2 position Physiological intakes Human study Plasma lipid profile LCAT activity |
本文献已被 PubMed SpringerLink 等数据库收录! |
|