The hypolipidemic effect of SU-13,437 in rats with natural endogenous hypertriglyceridemia

The oral administration of 25 mg 2-methyl-2-[p-(1,2,3,4-tetrahydro-1-naphthyl)-phenoxy] propionic acid (SU-13,437) per kilogram body weight per day in two-month-old female rats with naturally occurring hypertriglyceridemia resulted in a 31% decrease (P<0.01) in the serum triglyceride concentration after 14 days of treatment, compared with littermate controls receiving diluent (Polyethylene glycol-300) only. Phospholipid, cholesterol, free fatty acid, glucose, red blood cell and white blood cell concentrations were similar in the blood of treated and control animals after 14 days of treatment. Liver total and relative weight was increased as a result of SU-13,437 treatment (P<0.01). The liver total lipid concentration per 10 gm liver decreased (P<0.05) due to a decrease in triglyceride (P<0.01), cholesterol (P<0.01), and free fatty acid (P<0.05) concentration following treatment. The relative liver glycogen concentration was elevated in treated rats at 7 (P<0.01) and 14 (P<0.05) days of treatment.