| 单硫键聚乳酸/聚乙二醇共聚物胶束的制备及超声响应行为 |
| |
| 引用本文： | 李永文,佟锐,宣隽,张洪吉,夏和生. 单硫键聚乳酸/聚乙二醇共聚物胶束的制备及超声响应行为[J]. 高分子材料科学与工程, 2010, 26(6): 148-151 |
| |
| 作者姓名： | 李永文 佟锐 宣隽 张洪吉 夏和生 |
| |
| 作者单位： | 高分子材料工程国家重点实验室(四川大学),四川大学高分子研究所,四川,成都,610065;高分子材料工程国家重点实验室(四川大学),四川大学高分子研究所,四川,成都,610065;高分子材料工程国家重点实验室(四川大学),四川大学高分子研究所,四川,成都,610065;高分子材料工程国家重点实验室(四川大学),四川大学高分子研究所,四川,成都,610065;高分子材料工程国家重点实验室(四川大学),四川大学高分子研究所,四川,成都,610065 |
| |
| 基金项目： | 教育部新世纪人才资助计划(NCET-07-0583) |
| |
| 摘 要： | 以二环己基碳二亚胺为脱水剂,4-二甲氨基吡啶为催化剂,合成了含有中心硫醚键聚乳酸/聚乙二醇嵌段共聚物(PEG-S-PLA)。动态光散射和扫描电子显微镜结果表明此嵌段共聚物能自组装形成纳米球形胶束,并且可在高强度聚焦超声刺激下导致自组装结构破坏,通过粒径和形貌变化证实了结构的破坏。进一步用紫外吸收光谱研究高强度聚焦超声控制释放行为,结果表明,此新型刺激响应胶束体系对疏水药物的控制释放具有重要意义。
|
| 关 键 词： | 胶束 硫醚键聚乳酸/聚乙二醇嵌段共聚物 高强度聚焦超声 |
Preparation of PEG-S-PLA Micelles and the HIFU Controlled Release Behavior |
| |
| LI Yong-wen,TONG Rui,XUAN Juan,ZHANG Hong-ji,XIA He-sheng. Preparation of PEG-S-PLA Micelles and the HIFU Controlled Release Behavior[J]. Polymer Materials Science & Engineering, 2010, 26(6): 148-151 |
| |
| Authors: | LI Yong-wen TONG Rui XUAN Juan ZHANG Hong-ji XIA He-sheng |
| |
| Affiliation: | (State Key Laboratory of Polymer Materials Engineering of China (Sichuan University),Polymer Research Institute of Sichuan University,Chengdu 610065,China) |
| |
| Abstract: | Thioether is of particular interest due to its stability in plasma.To develop an high intensity focused ultrasound (HIFU)-responsive micelle system,polyethylene glycol/poly (l-lactic acid) with an internal thioether (PEG-S-PLA) was prepared through condensation polymerization.These copolymers were designed to form stable micelles in aqueous solution but to disintegrate into unimers under HIFU irradiation.Dynamic light scattering and scanning electron microscopy show that these copolymers are self-assembled into spherical micelles.The responsive behavior of micelles was investigated by the change of size and morphology.The HIFU-controlled release behavior was investigated by UV-vis spectra.The results show the interest of developing HIFU responsive micelles for controlled delivery applications. |
| |
| Keywords: | micelles PEG-S-PLA high intensity focused ultrasound |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
