Acute and critical care in neurology

When subjects select a prime from a visual display while leaving a distractor prime unselected, response time (RT) or response accuracy to a subsequent probe may be impeded if the distractor prime and probe are identical, or if they are related to one another. This phenomenon, negative priming (NP), has obvious implications for understanding perceptual selection. However, it is not known whether NP results from other kinds of selection processes. The present studies were designed to investigate whether NP occurs when primes are selected from working memory rather than from a visual display. In the two experiments, the subjects memorized two primes, selected one prime for further processing, and classified the contents of a probe display. Significant NP occurred in both Experiments. In Experiment 2, however, NP occurred only under easy-selection conditions; the effect was reversed under difficult-selection conditions. The findings indicate a role for NP in memory processing, but contrast with the results from perceptual selection studies showing greater NP under difficult-selection than under easy-selection conditions. The present finding suggests a complex and perhaps strategy-dependent relationship between memory selection difficulty and NP.