| 生物催化制备光学活性4-氯-3-羟基丁酸酯研究进展 |
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| 引用本文： | 孙志浩,何军邀.生物催化制备光学活性4-氯-3-羟基丁酸酯研究进展[J].化工进展,2006,25(6):623-628. |
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| 作者姓名： | 孙志浩 何军邀 |
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| 作者单位： | 江南大学生物工程学院生物催化研究室,工业生物技术教育部重点实验室,无锡,214036 |
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| 基金项目： | 国家高技术研究发展计划(863计划)
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国家研究发展基金 |
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| 摘 要： | 综述了生物催化制备光学活性4-氯-3-羟基丁酸酯(CHBE)的研究进展,介绍了生物催化外消旋体拆分和不对称还原方法制备光学活性CHBE的研究现状,重点阐述了反应介质选择、辅助底物和添加剂的选择、细胞热处理等一些控制不对称还原4-氯-3-氧代丁酸酯(COBE)立体选择性的方法。对生物催化制备光学活性CHBE的工业化前景进行了展望。
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| 关 键 词： | 生物催化 光学活性 4-氯-3-羟基丁酸酯 外消旋体拆分 不对称还原 |
| 文章编号： | 1000-6613（2006）06-0623-06 |
| 收稿时间： | 2005-12-19 |
| 修稿时间： | 2006-02-21 |
Preparation of optically active 4 - chloro - 3 - hydroxbutanoate ester by biocatalysis |
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| SUN Zhihao,HE Junyao.Preparation of optically active 4 - chloro - 3 - hydroxbutanoate ester by biocatalysis[J].Chemical Industry and Engineering Progress,2006,25(6):623-628. |
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| Authors: | SUN Zhihao HE Junyao |
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| Affiliation: | Laboratory of Biocatalysis, School of Biotechnology, Southern Yangtze University; Key Laboratory of Industrial Biotechnology, Ministry of Education, Wuxi 214036 |
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| Abstract: | The recent development of preparing optically active 4-chloro-3-hydroxbutanoate ester(CHBE) by biocatalysis is reviewed.The current research of racemic resolution and asymmetric reduction to prepare the optically active CHBE by biocatalysis is introduced.Several measures for controlling the stereo-selectivity of the asymmetric reduction of 4-chloro-3-oxobutanoate ester(COBE) to CHBE such as screening solvent,selection of co-substrate and additive,heat treatment of cells and so on,are presented.The prospect of industrial preparation of the optically active CHBE by biocatalysis is also discussed. |
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| Keywords: | biocatalysis optical activity 4 - chloro - 3 - hydroxbutanoate esters racemic resolution asymmetric reduction |
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