Amorphous magnetoelastic sensors for the detection of biological agents |
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| Authors: | Fei Xie Hong Yang Suiqiong Li Wen Shen Jeihui Wan Michael L. Johnson Howard C. Wikle Dong-Joo Kim Bryan A. Chin |
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| Affiliation: | Materials Research and Education Center, Auburn University, Auburn, AL 36849, USA;The University of TennesseeDepartment of Materials Science & Engineering tnieih@utk.edu;Beijing University of Aeronautics and AstronauticsSchool of Materials Science and Engineeringe-mail: zhangtao@buaa.edu.cn;Chinese Academy of ScienceInstitute of Physicse-mail: whw@aphy.iphy.ac.cn;Beijing University of Aeronautics and AstronauticsSchool of Materials Science and Engineeringe-mail: machaoli@buaa.edu.cn;University of Science and Technology Beijing State Key Laboratory for Advanced Metals and MaterialsE-mail: luzp@skl.ustb.edu.cn;Xi''an Jiaotong UniversitySchool of Materials Science and EngineeringE-mail: junsun@mail.xjtu.edu.cn |
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| Abstract: | Freestanding amorphous magnetoelastic (ME) biosensors were fabricated by two ways. One type with larger size, 2000 × 400 × 15 μm, 1000 × 200 × 15 μm and 500 × 100 × 15 μm, was made from an ME Fe40Ni38Mo4B18 ribbon, the other with smaller size 200 × 40 × 4 μm was manufactured by dual beam sputtering and non-traditional microelectronic fabrication techniques. Both platforms were immobilized with JRB7 phage and were developed for the real-time in vitro detection of Bacillus anthracis spores. The experimental results show that the measured sensitivity of the ME sensors agrees with theoretical predictions and the specificity of ME sensors coated with JRB7 phage for B. anthracis spore species is excellent. The 200 × 40 × 4 μm biosensor was found to have a detection limit of 102 cfu/ml and sensitivity of 13.1 kHz/decade. |
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