| 尿素催化合成乙酰水杨酸 |
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| 引用本文： | 郑广进,龙盛京.尿素催化合成乙酰水杨酸[J].工业催化,2010,18(6):48-50. |
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| 作者姓名： | 郑广进 龙盛京 |
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| 作者单位： | 广西医科大学药学院，广西 南宁 530021 |
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| 摘 要： | 以水杨酸和乙酸酐为原料,采用尿素作催化剂合成乙酰水杨酸。考察了温度、尿素用量、n(水杨酸)∶n(乙酸酐)和时间对反应的影响。正交试验结果表明,较适宜的反应条件为:n(水杨酸)∶n(乙酸酐)=1∶3,尿素用量为水杨酸质量的5%,反应温度85℃,反应时间60 min,此条件下,乙酰水杨酸收率达94.06%。
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| 关 键 词： | 精细化学工程 尿素 催化合成 乙酰水杨酸 正交试验 |
Synthesis of acetylsalicylic acid catalyzed by urea |
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| ZHENG Guangjin,LONG Shengjing.Synthesis of acetylsalicylic acid catalyzed by urea[J].Industrial Catalysis,2010,18(6):48-50. |
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| Authors: | ZHENG Guangjin LONG Shengjing |
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| Affiliation: | School of pharmacy, Guangxi Medical University, Nanning 530021, Guangxi, China |
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| Abstract: | Acetylsalicylic acid was synthesized using salicylic acid and acetic anhydride as raw materials and urea as the catalyst. Effects of reaction temperature, urea dosage, molar ratio of salicylic acid to acetic anhydride and reaction time were investigated. The results of the orthogonal test showed that acetylsalicylic acid yield of 94.06% was obtained under the optimum condition as follows： n（ salicylic acid）： n（acetic anhydride） = 1：3 ,urea dosage 5% of salicylic acid mass, reaction temperature 85 ℃, reaction time 60 min. |
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| Keywords: | fine chemical engineering urea catalytic synthesis acetylsalicylic acid orthogonal test |
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