Anomalies of the tracheobronchial tree in patients with esophageal atresia |
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Authors: | N Usui S Kamata S Ishikawa T Sawai H Okuyama K Imura A Okada |
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Affiliation: | Service Central Jacques Delarue d'Anatomie et de Cytologie Pathologiques, H?pital H?tel-Dieu, Paris, France. |
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Abstract: | Bone marrow examination revealed a lipid-laden histiocytosis in seven patients undergoing long-term total parenteral nutrition necessitated by extensive short-bowel surgical resection. Clinical abnormalities occurred during this treatment which required bone marrow examination. These included hepatosplenomegaly and peripheral blood cytopenia; the median time to the detection of these abnormalities was 64 months. The most striking change within the bone marrow was the presence of many pigment-laden histiocytes which had the typical morphology of sea-blue histiocytes seen in the so-called idiopathic sea-blue histiocyte syndrome. The occurrence of sea-blue histiocytosis in the bone marrow in association with long-term parenteral nutrition for short-bowel syndrome has not, to our knowledge, been reported previously and should now be considered in the differential diagnosis of bone marrow sea-blue histiocytosis. |
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