| 甲基丙二酸-(反式-1,2-二甲胺基环丁烷)合铂(II)的合成、结构及抗肿瘤活性 |
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| 引用本文： | 李军,丛艳伟,张林涛,王应飞,刘其星,郭明里,陈红娟,普绍平.甲基丙二酸-(反式-1,2-二甲胺基环丁烷)合铂(II)的合成、结构及抗肿瘤活性[J].贵金属,2019,40(S1):121-126. |
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| 作者姓名： | 李军 丛艳伟 张林涛 王应飞 刘其星 郭明里 陈红娟 普绍平 |
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| 作者单位： | 昆明贵金属研究所 稀贵金属综合利用国家重点实验室，昆明 650106;昆明贵研药业有限公司 云南省铂族金属抗肿瘤药物工程技术研究中心，昆明 650106,昆明贵研药业有限公司 云南省铂族金属抗肿瘤药物工程技术研究中心，昆明 650106,昆明贵研药业有限公司 云南省铂族金属抗肿瘤药物工程技术研究中心，昆明 650106,昆明贵研药业有限公司 云南省铂族金属抗肿瘤药物工程技术研究中心，昆明 650106,昆明贵研药业有限公司 云南省铂族金属抗肿瘤药物工程技术研究中心，昆明 650106,昆明贵研药业有限公司 云南省铂族金属抗肿瘤药物工程技术研究中心，昆明 650106,昆明贵研药业有限公司 云南省铂族金属抗肿瘤药物工程技术研究中心，昆明 650106,昆明贵研药业有限公司 云南省铂族金属抗肿瘤药物工程技术研究中心，昆明 650106 |
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| 基金项目： | 云南省科技创新平台建设计划(2016DH008) |
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| 摘 要： | 通过水解法合成了甲基丙二酸-(反式-1，2-二甲胺基环丁烷)合铂(Ⅱ)。采用元素分析、质谱(ESI-MS)、红外光谱(IR)和核磁共振氢谱(1H NMR)确证了该配合物的组成和化学结构。采用MTS法评价其抗肿瘤活性，发现该配合物对常见5种癌细胞的生长有明显的抑制活性。
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| 关 键 词： | 药物化学 铂化合物 合成 结构 抗肿瘤活性 |
| 收稿时间： | 2019/9/2 0:00:00 |
Synthesis, Structure and Antitumor Activity of Methyl Malonic Acid- [trans-1,2-dimethylamino cyclobutane] Platinum(II) Compound |
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| LI Jun,CONG Yanwei,ZHANG Lintao,WANG Yingfei,LIU Qixing,GUO Mingli,CHEN Hongjuan and PU Shaoping.Synthesis, Structure and Antitumor Activity of Methyl Malonic Acid- [trans-1,2-dimethylamino cyclobutane] Platinum(II) Compound[J].Precious Metals,2019,40(S1):121-126. |
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| Authors: | LI Jun CONG Yanwei ZHANG Lintao WANG Yingfei LIU Qixing GUO Mingli CHEN Hongjuan and PU Shaoping |
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| Affiliation: | State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals, Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China,Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China,Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China,Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China,Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China,Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China,Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China and Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China |
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| Abstract: | Platinum compound was synthesized from potassium chloroplatinite, methylmalonic acid and trans-1,2-dimethylamine cyclobutane (or oxalate) by hydrolysis , named methyl malonic acid-trans-1,2- dimethylamino cyclobutane] platinum(II) compound. It was analyzed by elemental analysis, ESI-MS, IR and 1H NMR. The structure and composition of the compound are consistent with the theory. MTS method was applied to evaluate its anti-tumor activity. The results showed that the compound has obvious inhibitory activity on the growth of Five common cancer cells. |
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| Keywords: | pharmaceutical chemistry platinum compound synthesis structure inhibitory activity |
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