| 来曲唑合成的研究 |
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| 引用本文： | 唐丽娟,曾艳霞,马伟光,刘玮炜,赵跃强.来曲唑合成的研究[J].淮海工学院学报,2006,15(4):38-40. |
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| 作者姓名： | 唐丽娟 曾艳霞 马伟光 刘玮炜 赵跃强 |
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| 作者单位： | 淮海工学院化学工程系 江苏连云港222005 |
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| 基金项目： | 江苏省海洋生物技术重点建设实验室基金资助项目(2006HS014)，淮海工学院学科建设基金资助项目(XK200309)，淮海工学院化学工程系科研课题(HGX05013) |
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| 摘 要： | 对抗癌药物来曲唑的合成方法进行了研究,以1-(4-氰基苄基)-1H-1,2,4-三氮唑为原料,分别与对氟苯腈或对氯苯腈在强碱环境中发生亲核取代反应,合成了目标产物,产率分别达到了70%和59%,并测试了产品熔点和红外光谱。以与对氟苯腈相比,对氯苯腈便宜易得,因此以1-(4-氰基苄基)-1H-1,2,4-三氮唑与对氯苯腈制备来曲唑的路线有工业化生产的价值。
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| 关 键 词： | 来曲唑 合成 抗癌药物 1 2 4-三氮唑 |
| 文章编号： | 1672-6685(2006)04-0038-03 |
| 收稿时间： | 2006-10-24 |
| 修稿时间： | 2006-12-02 |
Study on the Synthesis of Letrozole |
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| TANG Li-juan,ZENG Yan-xia,MA Wei-guang,LIU Wei-wei,ZHAO Yue-qiang.Study on the Synthesis of Letrozole[J].Journal of Huaihai Institute of Technology:Natural Sciences Edition,2006,15(4):38-40. |
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| Authors: | TANG Li-juan ZENG Yan-xia MA Wei-guang LIU Wei-wei ZHAO Yue-qiang |
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| Affiliation: | Dept. of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, China |
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| Abstract: | The synthetic method of anticancer drug Letrozole was studied.In the presence of alkali,the target compound was synthesized from 4-1-(1,2,4-triazolyl)methyl]-benzontrile and fluorobenzonitrile/chlorobenzonitrile by necleophilic substitution with the respective yield of 70% and 59%.The melting point of the product and IR spectra were characterized.Compared with fluorobenzonitrile,chlorobenzonitrile is cheaper,so the proposed synthetic method of Letrozole from 4-1-(1,2,4-triazolyl)-methyl]-benzontrile and chlorobenzonitrile is of great value in industrialized production. |
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| Keywords: | Letrozole synthesis anticancer drug 1 2 4-triazole |
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