| 液相色谱-串联质谱法同时测定化妆品中18种磺胺类相关化合物残留 |
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| 引用本文： | 钟吉强,郑荣,简龙海,刘畅,王柯.液相色谱-串联质谱法同时测定化妆品中18种磺胺类相关化合物残留[J].香料香精化妆品,2014(6):51-54. |
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| 作者姓名： | 钟吉强 郑荣 简龙海 刘畅 王柯 |
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| 作者单位： | 上海市食品药品检验所 |
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| 基金项目： | 上海市食品药品监督管理局课题(kt-20120726566) |
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| 摘 要： | 为建立化妆品中18种磺胺类相关化合物的LC-MS/MS测定法,将样品用丙酮提取,经SPE固相萃取柱净化富集,在C18色谱柱（4.6mm×50mm×2.7μm）上以甲醇-0.1%（体积分数）甲酸水溶液为流动相梯度洗脱,在ESI正离子MRM模式下检测。结果发现：18种化合物在10-800ng/mL的质量浓度范围内线性关系良好,加标回收率为78.6%-97.2%,检出限为25μg/kg。
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| 关 键 词： | 磺胺类相关化合物 液相色谱-串联质谱法 化妆品 |
Determination of Eighteen Kinds of Sulfonamide Residues in Cosmetics by LC-MS/MS Method |
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| ZHONG Jiqiang;ZHENG Rong;JIAN Longhai;LIU Chang;WANG Ke.Determination of Eighteen Kinds of Sulfonamide Residues in Cosmetics by LC-MS/MS Method[J].Flavour Fragrance Cosmetics,2014(6):51-54. |
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| Authors: | ZHONG Jiqiang;ZHENG Rong;JIAN Longhai;LIU Chang;WANG Ke |
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| Affiliation: | ZHONG Jiqiang;ZHENG Rong;JIAN Longhai;LIU Chang;WANG Ke;Shanghai Institute for Food and Drug Control; |
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| Abstract: | A LC-MS/MS method for determination of 18 kinds of sulfonamide residues in cosmetics was established.The sample was extracted by acetone,then purified by SPE.The chromatographic separation was carried out on a C18 column（4.6mm × 50 mm ×2.7μm）.Mixture of methanol and 0.1%（volume fraction）formic acid-water solution was used as mobile phase for gradient elution.The tests were carried out in the ESI positive ion MRM mode.The results showed that the linearity ranged from 10 to 800ng/mL,all recoveries were between 78.6%to 97.2%,the limit of detection was 25μg/kg. |
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| Keywords: | sulfonamide LC-MS/MS cosmetics |
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