维生素K3合成研究

以间甲酚为原料，经加压氧气催化氧化得到2-甲基苯醌，再在加压和二甲基亚砜溶剂条件下与1，3-丁二烯进行Diels—Alder加成反应，并在一锅中直接氧化脱氢生成维生素K3，产品总收率为75％。本方法具有原料廉价易得，产品收率高，污染排放较少，反应条件温和，容易工业化等优点。

Synthesis of Vitamin K3

m- Cresol was chosen as raw material which oxidized by oxygen under pressure to give 2 - methyl -1,4- benzoquione, The product was then subject to a Diels- Alder addition with 1,3- butadiene in the presence of DMSO as solvent, and the addition product was subsequently to oxidative dehydrogenation to give vitamin K3,,The total yield of product reached 75 %. The process possess the advantages of cheap in the raw material, high in the yields, less in pollution produced and mild in the reaction conditions, which is adapt to industrialization.