Tolyporphins J and K, two further porphinoid metabolites from the cyanobacterium Tolypothrix nodosa |
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| Authors: | MR Prinsep GM Patterson LK Larsen CD Smith |
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| Affiliation: | Department of Chemistry, University of Waikato, Private Bag 3105, Hamilton, New Zealand. michele@waikato.ac.nz |
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| Abstract: | Two new porphinoids, tolyporphins J (1) and K (2), have been isolated from the terrestrial cyanobacterium, Tolypothrix nodosa (HT-58-2) and identified by NMR and mass spectral analysis. The activities of tolyporphins J and K in cell sensitization and drug accumulation assays for multidrug resistance (MDR) reversal were compared with those of tolyporphin A. Unusual NMR spectroscopic shifts were observed for tolyporphin J (1) in CDCl3. |
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