| 硫酸胍基丁胺的绿色合成工艺研究 |
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| 引用本文： | 叶珊珊,王建伟,叶露,邹健锋,单伟光.硫酸胍基丁胺的绿色合成工艺研究[J].浙江化工,2010,41(9):5-7. |
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| 作者姓名： | 叶珊珊 王建伟 叶露 邹健锋 单伟光 |
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| 作者单位： | 1. 浙江工业大学药学院,浙江,杭州,310014
2. 嘉兴市红日化工有限公司,浙江,嘉兴,314004 |
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| 基金项目： | 浙江省科技计划资助项目 |
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| 摘 要： | 硫酸胍基丁胺是一种极具开发价值的戒毒类药物,市场运用前景广阔。本文以1,4-二溴丁烷与邻苯二甲酰亚胺钾为原料,经取代、胺解和胍基化等三步反应制得硫酸胍基丁胺,总收率为33.9%,产品含量99.5%。
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| 关 键 词： | 硫酸胍基丁胺 1 4-丁二胺 O-甲基异脲硫酸盐 |
Green Process for the Preparation of Agmatine Sulfate |
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| YE Shan-shan,WANG Jian-wei,YE Lu,ZOU Jian-feng,SHAN Wei-guang.Green Process for the Preparation of Agmatine Sulfate[J].Zhejiang Chemical Industry,2010,41(9):5-7. |
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| Authors: | YE Shan-shan WANG Jian-wei YE Lu ZOU Jian-feng SHAN Wei-guang |
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| Affiliation: | YE Shan-shan1,WANG Jian-wei1,SHAN Wei-guang1,YE Lu1,ZOU Jian-feng2(1.College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou 310014,China,2.Jiaxing Red Sun Chemical Industry Co.,Ltd.,Jiaxing 314004,China) |
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| Abstract: | Agmatine sulfate is a detoxification drug with great development value and broad market foreground.It was synthesized with 33.9% overall yield and content of 99.5% by three-step reactions through substitution,aminolysis and Guanidine reaction from the starting materials: 1,4-butylenedibromide and phthalimide potassium. |
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| Keywords: | agmatine sulfate 1 4-butanediamine O-methylisourea hemisulfate |
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