不同菌种卡介苗人体免疫应答比较

我们于1983～1991年,分别用六株菌种制备的六种试制苗和全国五个生物制品研究所生产的5种成品苗,在杭州市、大连市和辽宁省3个点,对17524名新生儿接种,分别于接种后不同时间用PPD作皮肤试验进行免疫反应观察。结果表明,试制苗大连点12周的阳性率以上海株苗、巴西株苗为高,北京株苗为低;5年持续阳性率以上海株苗为最高,北京株苗为最低。在杭州点,以上海株苗和日本株苗为最高,亦以北京苗为低。成品苗杭州点和辽宁点12周的阳性率以上海所苗为最高,兰州所苗为最低。综合评议均以上海所苗为优。其淋巴结化脓仅出现在活菌数较高的制品中,发生率不超过1‰。

Comparison of the Immune Response of Newborns Vaccinated with Various Freeze-dried BCG

From 1983 to 1991, 17 524 newborns resided in Hangzhou City, Dalian City and Liaoning Provinces were vaccinated with 6 BCG trial products made from different strains: Brazil, Bei- jing, Japan, Changchun-Shanghai, Shanghai and Denmark and with 5 BCG final products manufac tured by 5 Institutes of Biological Products from Shanghai, Beijing, Changchun, Chengdu and Lanzhou. The immune responses were detected by skin test with PPD. In Dalian, the results showed that the 12-weeks-positive rates of BCG trial products made from Shanghai and Brazil strain were the highest, and that of BCG trial product made from Beijing strain was the lowest. The 5-years-positive rate of BCG trial products made from Shanghai strain was the highest, and that of BCG trial product made from Beijing strain was the lowest. In Hangzhou, the results also showed that the immune re sponse of BCG trial products made from Shanghai and Japan strains were the best, and that of BCG tri al product made from Beijing strain was the worst. In Hangzhou and Liaoning, the results showed that the 12-weeks-positive rate of BCG final product manufactured by Shanghai Institute of Biological Prod- ucts was the highest, and that of BCG final product manufactured by Lanzhou Institute of Biological Products was the lowest. The BCG final product from Shanghai Institute might lead to lymph node suppuration when the viable count of bacteria was high in some lots, but the proba- bility of occurrence was not more than 1.