Experimental and computational characterization of designed and fabricated 50:50 PLGA porous scaffolds for human trabecular bone applications |
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Authors: | Eiji Saito Heesuk Kang Juan M Taboas Alisha Diggs Colleen L Flanagan Scott J Hollister |
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Affiliation: | (1) Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA;(2) Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA;(3) Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA;(4) Department of Orthopedics Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA; |
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Abstract: | The present study utilizes image-based computational methods and indirect solid freeform fabrication (SFF) technique to design
and fabricate porous scaffolds, and then computationally estimates their elastic modulus and yield stress with experimental
validation. 50:50 Poly (lactide-co-glycolide acid) (50:50 PLGA) porous scaffolds were designed using an image-based design technique, fabricated using indirect
SFF technique, and characterized using micro-computed tomography (μ-CT) and mechanical testing. μ-CT data was further used
to non-destructively predict the scaffold elastic moduli and yield stress using a voxel-based finite element (FE) method,
a technique that could find application in eventual scaffold quality control. μ-CT data analysis confirmed that the fabricated
scaffolds had controlled pore sizes, orthogonally interconnected pores and porosities which were identical to those of the
designed files. Mechanical tests revealed that the compressive modulus and yield stresses were in the range of human trabecular
bone. The results of FE analysis showed potential stress concentrations inside of the fabricated scaffold due to fabrication
defects. Furthermore, the predicted moduli and yield stresses of the FE analysis showed strong correlations with those of
the experiments. In the present study, we successfully fabricated scaffolds with designed architectures as well as predicted
their mechanical properties in a nondestructive manner. |
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