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DNA biosensor by self-assembly of carbon nanotubes and DNA to detect riboflavin |
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| Authors: | Jing Li Yunhuai Zhang Tongyi Yang Huai Zhang Yixuan Yang Peng Xiao |
| Affiliation: | 1. College of Chemistry & Chemical Engineering. Chongqing University, ChongQing, 400044, PR China;2. School of Life Science. NanJing University, Nanjing, 210093, PR China;3. Liming Research Institute of Chemical Industry, LuoYang, 471001, PR China;4. State Key Laboratory of Chemical Resource Engineering. Beijing University of Chemical Technology, Beijing 100029, PR China;5. College of Mathematics & Physics, Chongqing University, Chongqing 400044, PR China |
| Abstract: | The fabrication of biosensors via self-assembly of single-walled carbon nanotubes (SWNTs) and DNA on a platinum electrode was presented in this paper. The carboxylic SWNTs were assembled on an amine-modified platinum electrode surface and followed by the assembly of NH2-DNA with the carboxyl-amine coupling. The decorated surface was characterized by Field Emission Electron Microscopy (FEG-SEM) and electrochemical experiments, which showed that the reaction of DNA–SWNTs biosensor was quasi-reversible. The mechanism of DNA and riboflavin (VB2) was studied by cyclic voltammetry and UV–Vis spectroscopy. The fabricated SWNTs-reinforced biosensor exhibits high sensitivity and low detection limit for the tested VB2 compared to the reported methods. |
| Keywords: | Self-assembly Single-walled carbon nanotube DNA Riboflavin Cyclic voltammetry |
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