| 白藜芦醇对兔动脉粥样硬化基质金属蛋白酶表达的影响 |
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| 引用本文： | 李运田,柳杨,杜大勇,王芳.白藜芦醇对兔动脉粥样硬化基质金属蛋白酶表达的影响[J].压电与声光,2010(4). |
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| 作者姓名： | 李运田 柳杨 杜大勇 王芳 |
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| 作者单位： | 解放军第305医院全军冠心病诊疗中心; |
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| 基金项目： | 全军“十一·五”医药卫生科研基金项目(06G145)~~ |
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| 摘 要： | 目的探讨白藜芦醇对实验性动脉粥样硬化兔基质金属蛋白酶(MMP)表达的影响。方法选择新西兰纯种雄性大白兔50只随机分为三组,正常对照组10只,模型组20只,白藜芦醇组20只。采用液氮冻伤术建立动脉硬化模型,造模2个月后采用液氮冻伤术激发动脉硬化斑块破裂,模后2个月及激发试验后48h后分别对三组动物测定MMP-1、9的浓度。结果模型组造模后2个月MMP-1、9的浓度分别为(50.74±5.49)ng/ml和(337.69±8.98)ng/ml,同期白藜芦醇组MMP-1、9的浓度分别为(41.33±9.58)ng/ml和(309.83±10.59)ng/ml(P<0.01),激发试验48h后模型组MMP-1、9的浓度分别为(100.35±6.58)ng/ml和(869.56±12.37)ng/ml,同期白藜芦醇组MMP-1、9的浓度分别为(61.68±11.69)ng/ml和(411.24±15.74)ng/ml(P<0.01)。结论白藜芦醇能够降低MMP-1、9的浓度,从而预防和延缓动脉硬化的发生。
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| 关 键 词： | 动脉硬化 白藜芦醇 基质金属蛋白酶 兔 |
Effect of resveratrol on expression of matrix metalloproteinase in rabbits with athrosclerosis |
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| LI Yun-tian,LIU Yang,DU Da-yong,WANG FangCentre of Coronary Heart Disease,Chinese PLA Hospital,Beijing,China.Effect of resveratrol on expression of matrix metalloproteinase in rabbits with athrosclerosis[J].Piezoelectrics & Acoustooptics,2010(4). |
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| Authors: | LI Yun-tian LIU Yang DU Da-yong WANG FangCentre of Coronary Heart Disease Chinese PLA Hospital Beijing China |
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| Affiliation: | LI Yun-tian,LIU Yang,DU Da-yong,WANG FangCentre of Coronary Heart Disease,Chinese PLA 305 Hospital,Beijing 100017,China |
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| Abstract: | Objective To study the effect of resveratrol on expression of matrix metalloproteinase (MMP) in rabbits with experimental atherosclerosis. Methods Fifty New Zealand healthy rabbits were randomly divided into normal control group(n=10), atherosclerosis model group(n=20), and resveratrol group(n=20).Two months after an atherosclerosis model was established using liquid nitrogen, cold injury was induced to provoke rupture of atherosclerosis plaque. Levels of MMP-1 and 9 were measured 2 months after model estab... |
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| Keywords: | Atherosclerosis Resveratrol Matrix Metalloproteinases Rabbits |
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