| 氟伐他汀对2型糖尿病合并高胆固醇血症患者的抗氧化作用 |
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| 引用本文： | 管静芝,玉泽直树.氟伐他汀对2型糖尿病合并高胆固醇血症患者的抗氧化作用[J].压电与声光,2010(2):133-134. |
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| 作者姓名： | 管静芝 玉泽直树 |
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| 作者单位： | [1]解放军总医院第309临床部肿瘤中心,北京100091 [2]弘前大学医学部附属医院内三科,日本036-8562 |
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| 基金项目： | 北京市传感器重点实验室开放课题基金，北京市教委科技创新平台基金? |
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| 摘 要： | 目的调查氟伐他汀对2型糖尿病合并高胆固醇血症患者体内氧化压力的影响以及与降脂作用的相关性。方法糖尿病合并高脂血症患者41例，男21例，女20例，平均年龄（56．7±6．0）岁，均在日本弘前大学附属医院收集。每晚服用20mg氟伐他汀，于用药前及用药后4、8、12周分别测定血浆中低密度脂蛋白（LDL），LDL size、LHPO、TBARS的动态变化。结果血浆LHPO，TBARS、LDL—C在用药的第8周（分别为19．4±8．1 vs43.3±13．1nmol／mg LDLpm；5．33±0．97vs8．83±1．11nmol／mL；125±9vs157±12mg／dL，P〈0．05）和12周（分别为14．4±5．1vs43．3±13．1nmol／mg LDLpro；2．3±0．3vs8．83±1．11nmol／mL；131±5vs157±12mg／dL，P〈0．05）明显降低，LDL size无统计学差异。结论氟伐他汀能够显著降低患者血中的LHPO、TBARS、LDL，表明对2型糖尿病合并高脂血症患者有抗氧化作用．且与其抗血脂的作用相关．
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| 关 键 词： | 氟伐他汀 糖尿病 脂蛋白类，LDL 氧化性应激 危险因素 |
Inhibitory effect of fluvastatin on oxidation stress in patients with type 2 diabetic mellitus complicated by hyperlipidemia |
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| GUAN Jing-zhi,Tamasawa Naoki.Inhibitory effect of fluvastatin on oxidation stress in patients with type 2 diabetic mellitus complicated by hyperlipidemia[J].Piezoelectrics & Acoustooptics,2010(2):133-134. |
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| Authors: | GUAN Jing-zhi Tamasawa Naoki |
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| Affiliation: | GUAN Jing-zhi1,Tamasawa Naoki2 1Department of Tumor center,309 Clinical Division,Chinese PLA General Hospital,Beijing 100091,China,2Third Department of Internal Medicine,Hirosaki University School of Medicine,036-8562,Japan |
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| Abstract: | Objective To investigate the inhibitory effect of fluvastatin on oxidation stress and its relation with lipid decrease in patients with type 2 diabetes mellitus complicated by hyperlipidemia.Methods Forty-one patients(21 males and 20 females with a mean age of 56.7 years)selected from the Affiliated Hospital of Hirosaki University in Japan,were treated with 20mg fluvastastin once a day in the evening for 12 weeks.Changes in plasma LDL,LDL-C,LHPO,and TBARS were assayed at weeks 4,8,and 12 before and after ad... |
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| Keywords: | Fluvastatin Diabetes Mellitus type 2 Lipoproteins LDL Oxidative Stress Risk Factors |
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