| 乳铁蛋白免疫调节功能初探 |
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| 引用本文： | 李娜,胡志和,庞广昌,刘传国,郭莉.乳铁蛋白免疫调节功能初探[J].食品科学,2007,28(9):532-535. |
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| 作者姓名： | 李娜 胡志和 庞广昌 刘传国 郭莉 |
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| 作者单位： | 天津市食品生物技术重点实验室,天津商学院生物技术与食品科学学院,天津,300134 |
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| 摘 要： | 目的：研究乳铁蛋白的免疫调节作用。方法：采用MTT法检测乳铁蛋白对小鼠外周血单个核细胞以及脾淋巴细胞增殖的影响；利用角叉菜胶所致大鼠足趾肿胀模型研究其抗炎症活性。结论：乳铁蛋白对小鼠外周血单个核细胞的增殖具有显著抑制作用，且抑制程度与浓度有关。在浓度达100μg/ml以上时，抑制效果非常显著（p〈0.001），浓度达1000μg/ml时，抑制作用最为明显。此外，乳铁蛋白具有抗炎症作用。
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| 关 键 词： | 乳铁蛋白 淋巴细胞增殖 免疫抑制 抗炎 |
| 文章编号： | 1002-6630（2007）09-0532-04 |
| 修稿时间： | 2007-07-25 |
Study on Immunoregulating Effect of Lactoferrin |
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| LI Na,HU Zhi-he,PANG Guan-chang,LIU Chuan-guo,GUO Li.Study on Immunoregulating Effect of Lactoferrin[J].Food Science,2007,28(9):532-535. |
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| Authors: | LI Na HU Zhi-he PANG Guan-chang LIU Chuan-guo GUO Li |
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| Affiliation: | Tianjin Key Laboratory of Food Biotechnology, Department of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China |
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| Abstract: | Objective:To study the regulating function of immunity for lactoferrin.Methods:M TT method was used to observed the influence of lactoferrin on the lymphoproliferation activity of peripheral blood mononuclear cells and spleen cells and rat's hind paw edema induced by carrageenan were used to investigate the anti-inflammatory effect of it.Result:Lf can inhibit the growth of lymphocytes T,B-cell and the effet depend on dose.Furthermore,Lf exerts a definite anti-inflammatory effect on mice. |
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| Keywords: | lactofemn lymphoproliferation immunorepression anti-inflammation |
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