New Synthetic Approaches to PAHs and their Carcinogenic Metabolites |
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| Authors: | Ronald G. Harvey Fang-Jie Zhang |
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| Affiliation: | Ben May Institute for Cancer Research , University of Chicago , Chicago , Illinois , USA |
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| Abstract: | Syntheses of sterically crowded derivatives of benzo[ s ]picene and naphtho[1,2,3,4- rst ]pentaphene and their bis -dihydrodiol metabolites via a method that involves in the key steps double Suzuki coupling of aryl bis -boronic acid and o -bromoaryl aldehyde precursors are described. |
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| Keywords: | Carcinogenic Polycyclic Aromatic Hydrocarbons 6,7-dim-ethylbenzo[ s ]picene Naphtho[1,2,3,4- rst ]-pentaphene Nonplanarity Suzuki Coupling |
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